Harley Quinn and Poison Ivy are taking their show on the road and moving to a new city in Harley Quinn. Max released the first trailer for season five, previewing the mayhem that will follow them when they put Gotham in their rearview.

Things are going great for Harley (Kaley Cuoco) and Ivy (Lake Bell) – minus the fact that Gotham is being attacked by giant rats, among other threats. So, the ladies decide that it’s time to move to Metropolis, where Lena Luthor asks Ivy to run a green initiative. The trailer catches up with Harley’s friends like Bane (James Adomian), Frank the Plant (J.B. Smoove), King Shark (Ron Funches) and his brood of bite-y babies, and Clayface (Alan Tudyk).

Harley and Ivy will have to save the day once again, as Brainiac (Stephen Fry) is in space and ready to attack, and there are zombies and killer AI in Metropolis. The trailer also shows Red X, Dick Grayson’s “villain” persona from the Teen Titans animated series, who is likely seeking revenge against Harley for accidentally killing him in season four.

The voice cast for season five includes Aisha Tyler as Lena Luthor, Natalie Morales as Lois Lane, James Wolk as Superman, Christopher Meloni as Commissioner Gordon, Harvey Guillén as Dick Grayson/Nightwing, and Tony Hale as Dr. Psycho.

Harley Quinn season five will start streaming on Max on January 16, 2025. The trailer features some adult language; it can be viewed on YouTube.